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References: Semaglutide is a glucagon like peptide-1 receptor agonist with cardiovascular benefits for the management of type 2 diabetes

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Healthcare professionals should provide comprehensive counselling about realistic expectations, potential side effects, and the importance of lifestyle modifications alongside pharmacotherapy for optimal outcomes in cardiometabolic health

Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, whereas semaglutide acts on GLP-1 receptors alone and tirzepatide targets both GIP and GLP-1 receptors

A 2025 study in BMC Medicine found that within just eight weeks of stopping anti-obesity medications (AOMs), participants experienced significant weight regain compared to those who continued treatment