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Its a critical, non-negotiable element in the chain of quality that ensures your experiments are valid and your results are reproducible
Yang, Y
The EFSA notes, The inherent uncertainty of this [factorial] approach is reflected in the wide range of cobalamin intake calculated to compensate for estimated daily losses, depending on the assumptions taken (EFSA, 2015). Appendix D
Have used it and found it gentle to skin
Ideally, you want it hot enough that the water in the pot simmers, but does not boil
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