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When the amount of tyrosinase is reduced, the melanin formation process is also prevented, leading to brighter skin and less darkening

If morphology and immunohistochemistry are not contributory in assigning the melanocytic tumor to a given lineage, molecular analysis guided by morphology may be implemented as follows: - Identification of hotspot mutations of BRAF (codon 600) and NRAS [exon 2 (odons 12, 13), exon 3 (codons 59, 61), and of exon 4 (codons 117, 146)]

Here is what the evidence actually says, including the parts that require clinical judgment

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