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CdLS can also stem from mutations on the SMC3 gene of chromosome 10 [389] and SMC1L1 gene [390]
Interestingly, the Phase 2 data stratified by BMI showed that participants with BMI over 35 achieved greater absolute weight loss in pounds, even though the percentage weight loss was comparable to or slightly lower than lighter participants
Patients with established cardiovascular disease including previous myocardial infarction, stroke, or peripheral arterial diseaseare particularly suitable candidates, given the proven cardiovascular benefits of both drug classes
The cause and effect of errors in the control mechanisms of GCL are slowly being unravelled by researchers and is the subject of several excellent reviews [2-6]
& Trautmann, M
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