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KPV briefing document ( FDA

Ortiz, D

Key diagnostic elements include: Cyclical symptom pattern: Skin symptoms recur in a predictable, monthly patternmost often flaring 57 days before menstruation and improving rapidly with the onset of menses, when progesterone levels fall

92 Bladder biopsy may be indicated to exclude other pathologies if a lesion of uncertain nature is present but is not part of the routine diagnostic process and presents a risk of perforation