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Melatonin Melatonin, a hormone synthesized primarily by the pineal gland and locally in skin cells, plays a critical role in protecting melanocytes from oxidative stress by acting as a potent antioxidant and modulating cellular defense mechanisms 196

At the end of the study, the authors observed improved dermal density, reduced periorbital wrinkles, and skin smoothness in the treatment group

This significantly elevates Angiotensin II (Ang II) levels, a key RAAS mediator, which induces intestinal epithelial injury through four main pathways: (1) Ang II selectively inhibits P-glycoprotein (Pgp) function and membrane expression in intestinal epithelial cells via AT1 receptor-mediated PI3K/Akt-p38 MAPK signaling

The objective of this review is to provide a comprehensive and structured synthesis of the immunopathogenesis of HT, integrating established knowledge with emerging research areas including oxidative stress, gut microbiota, and epigenetic modifications, while also summarizing current clinical, diagnostic, and therapeutic perspectives (Fig

In animal models, Delta Sleep-Inducing Peptide has been suggested to regulate blood pressure, heart rate, thermogenesis, and the lymphokine system