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People who should be more cautious include those with: a history of certain thyroid cancers past serious pancreas problems serious stomach emptying disorders some rare genetic conditions People who are pregnant, trying to become pregnant, or breastfeeding should also talk with their providers about the risks and benefits of staying on or starting GLP-1 treatment

This dual mechanism is what separates tirzepatide from earlier GLP-1 receptor agonists and explains its superior weight loss results in clinical trials

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Over extended periods of time, however, levodopa becomes less effective, and increased doses are needed

a molecule that simultaneously activates three metabolic receptors: GLP-1, GIP and the glucagon receptor