Notably, PGRMC1 also binds other cytochrome P450 enzymes, such as cytochrome P450 family 3 subfamily A member 4 (CYP3A4), suggesting that individual variability in PGRMC1 function may influence broader drug metabolism pathways [49]
Chung, E., Genco, M., Megrelis, L
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This selective targeting strategy represents a precision-based approach to senolysis, focusing on restoring intrinsic apoptosis rather than inducing external stress
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