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The precise mechanisms by which amlodipine relieves angina have not been fully delineated, but are thought to include the following: Exertional Angina In patients with exertional angina, amlodipine besylate reduces the total peripheral resistance (afterload) against which the heart works and reduces the rate pressure product, and thus myocardial oxygen demand, at any given level of exercise

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It is intended only for properly supervised in vitro experimentation or authorized non-human preclinical research conducted by trained and qualified personnel

Oz HS, Chen TS

Caution is advised in patients with a history of pancreatitis or severe gastrointestinal disease