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The latter include synaptic protection, improvements in cognition, learning and motor function, amyloid pathology-ameliorating properties (A, Tau, and -synuclein), the suppression of Ca 2+ deregulation and ER stress, potent anti-inflammatory effects, the blockage of oxidative stress, mitochondrial dysfunction and apoptosis pathways, enhancements in the neuronal insulin sensitivity and energy metabolism, functional improvements in autophagy and mitophagy, elevated BDNF and glial cell line-derived neurotrophic factor (GDNF) synthesis as well as neurogenesis

Primary care physicians should prioritize management of diabetes mellitus with a target HbA1c of 7% or lower while being mindful of large reductions of HbA1c when starting diabetes medications such as GLP-1 receptor agonists

Each person reacts differently

Maintain adequate fluid intake and seek medical review if you are unable to keep fluids down

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