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Intrapatient changes in CT-Based body composition after initiation of semaglutide (Glucagon-Like Peptide-1 Receptor Agonist) therapy
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(Switzerland, 2019)
More specifically speaking, GLP-1 receptor activation facilitates the presynaptic release of GABA into RGCs via the Gs/cAMP/PKA/Phospholipase C (PLC)/IP3/Ca2+/CaM signaling pathway, ultimately increasing the GABAergic miniature inhibitory postsynaptic currents (m-IPSCs) frequency and contrast sensitivity ( The GABAergic modulation ability of GLP-1RAs is more thoroughly studied in brain tissues and cells
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