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As mentioned above, decreased Nrf2 expression and protein levels, and concomitantly, a lower activity of antioxidant defense, are found in tissues from COPD patients

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN: Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

Obesity is associated with pronounced disruption in circadian clock gene expression within adipose tissue 1,10

Despite the pharmacokinetic limitations, irregular adsorption and fast catabolism, the l-dopa became the standard oral pharmaceutical therapy of PD in the last fifty years [7]