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Community reports on AnabolicMinds and Reddit are split between "I felt nothing on oral capsules" and "this works as well as cardarine," and the published bioavailability concern is the simplest explanation for the variance

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While selectivity over classical ERs is reported at relevant concentrations, nuclear-receptor cross-reactivity and downstream network effects remain theoretical risks in longer or higher-exposure studies

Semaglutide is a GLP-1 receptor agonist analog