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This triple-action mechanism distinguishes it from existing approved therapies such as semaglutide (GLP-1 receptor agonist only) or tirzepatide (GLP-1/GIP dual agonist)

doi: 10.1038/nature02440 107 LpezMLageRSahaAKPrez-TilveDVzquezMJVarelaLet al

After de-duplication and screening based on inclusion and exclusion criteria, 123 meta-analyses (115 based on RCTs and 8 based on observational studies) with 464 outcomes were included in this umbrella review (Fig

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