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In laboratory trials it has been shown to cause tumors in the thyroid (including cancer) in some cases
With this compound, weight losses of up to 22% are generated in obese individuals [42], and several of the phase III SURPASS trials of patients with T2DM have shown reductions of HbA 1c to values at or below 5.7% (a completely normal value) in more than 50% of the patients, accompanied by weight losses in the order of 12% [43]
Retatrutide pushed that number to 16% at 4 mg, 22% at 8 mg, and 33-34% at 12 mg
iScience 27 , 109504 (2024)
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