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B12 deficiency is common, especially in people who follow a vegetarian or vegan diet

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Animal studies show that gadolinium can cause low glutathione levels.[ref] Mercury is another heavy metal that utilizes glutathione in the detoxification pathways.[ref] Arsenic exposure causes increased glutathione usage

These effects reflect tirzepatide's intended mechanismslowing gastric emptying and enhancing satiety signals in your brainand generally diminish as your body acclimates