The STEP trials (conducted 20182021) evaluated once-weekly semaglutide in over 4,500 adults with obesity, showing that the medication produced sustained weight loss of 1015% body weight reduction over 68 weeks, with adverse events primarily limited to gastrointestinal symptoms like nausea and constipation that typically resolve within weeks
29 Similarly, another study found that initial CLNs with poor preparation had an adenoma detection rate of 25%, which increased to 33.8% upon repeat examination, 30 highlighting the risk of missed lesions due to insufficient visualization
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The 9mg addition may eventually prove to be the ideal maintenance dose, capturing most of the 12mg efficacy with fewer side effects than either the 8mg or 12mg tiers
The medication provides a neurohormonal reset that allows you to adhere to lower caloric intake without the constant struggle against hunger that characterizes traditional dieting