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In my experience, injections in the skeletal muscles (intramuscular injections) result in a more dramatic improvement in symptoms including energy and weight loss
And while results can be impressive in the short term, the long-term picture is more complex: in one clinical study, participants regained two-thirds of their lost weight within a year of stopping treatment
It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
4 weeks post-injection, we administered DREADDs ligand clozapine-N-oxide (CNO, 1 mg/kg body weight) via intraperitoneal (i.p.) route
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