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Zepbound carries a boxed warning for the risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Common side effects of naltrexone/bupropion include: Nausea and vomiting (particularly during dose titration) Headache and dizziness Constipation or diarrhoea Insomnia and dry mouth Increased blood pressure and heart rate Nausea is especially pertinent in post-bariatric patients, who may already be prone to gastrointestinal symptoms

That is why the next step should be better prospective research, not protocol certainty

Marino, S., Hogue, I

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