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Some people experience mild digestive discomfort when starting supplementation

Phentermine is a sympathomimetic amine that suppresses appetite through central nervous system stimulation, whilst topiramateoriginally developed as an antiepilepticcontributes to weight loss through multiple pathways including appetite suppression and increased satiety

doi: 10.2174/1566524023666230529093314 9 AthaudaDMaclaganKSkeneSSBajwa-JosephMLetchfordDChowdhuryKet al

Carbonyl cyanide- p -trifluoromethoxyphenylhydrazone (FCCP)-stimulated respiration was lower than ADP-stimulated respiration, a pattern observed when FCCP or substrates become limiting and previously reported in Seahorse assays using isolated mitochondria 6,14