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These include not only effects of weight loss, but also improvements in endothelial function, reductions in low-grade inflammation (evidenced by a significant decrease in high-sensitivity C-reactive protein levels), and potential plaque stabilization [73]
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When there is a compelling need, in other subjects, to minimize the risk of hypoglycemia, DPP-4 inhibitors, thiazolidinediones, SGLT2 inhibitors, or GLP-1 receptor agonists may be added, except when cost is a major issue, in case thiazolidinediones or sulfonylureas could be given
In addition, GLP-1RAs, reduce pancreatic islet -cell apoptosis, stimulate the proliferation and differentiation of -cells, and decrease body weight by suppressing food intake in patients with T2DM [8, 41,42,43]
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