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Fluid retention and swelling

Tesamorelin is a synthetic 44-amino-acid analog of growth hormone-releasing hormone (GHRH), modified at the N-terminus with a trans-3-hexenoyl group to improve stability

Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use

Psychiatry 5 , 100107 (2011)