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As with any growth-factor therapy, clinical oversight is crucial to ensure balanced dosing and to avoid overstimulation of growth pathways

Apart from the PPP, two subtypes of isocitrate dehydrogenase (IDH) isoenzymes can also generate NADPH based on their intracellular localization: mitochondrial NADP + -dependent IDH ( Idh2 ), as well as cytosolic and peroxisomal NADP + -dependent ICDH ( Idh1 )