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LPS triggers systemic inflammation through the TLR4-NF-B pathway, promoting the release of pro-inflammatory cytokines and directly exacerbating myocardial apoptosis, fibrosis, and microvascular obstruction, thus forming an injury-translocation-inflammation-worsened injury cascade (Snelson et al., 2025)
Wang J, Wang H, Li Z, Wu Q, Lathia JD, McLendon RE, et al
This allows for weekly dosing, which changes how patients interact with the treatment
However, understanding safety data in context remains essential
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