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Transcellular Pathway Transcellular Diffusion Transcellular diffusion takes place at the luminal and abluminal membrane of BECs (38) and is restricted to gases such O 2 and CO 2 (36, 37) of 36 h) are believed to be related to the activation of brain-derived proteases such as MMP-9, neuroinflammation, and factors that promote vascular remodeling such as vascular endothelial growth factor (VEGF) (66)