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Once GHK-Cu reaches damaged tissue, the peptide releases its copper payload to activate lysyl oxidase (critical for collagen cross-linking), superoxide dismutase (SOD for antioxidant defense), and multiple matrix metalloproteinases involved in tissue remodeling [1]
It has been shown that AMPK agonist metformin can reduce seizure severity in animal model studies (Sanz et al
The picture changes substantially for non-topical routes
Krekels EH, van Ham S, Allegaert K, de Hoon J, Tibboel D, Danhof M, et al
doi: 10.1136/gut.6.5.472
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