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Background: Incretins were discovered after it was observed that administration of an oral glucose load leads to a much greater stimulation of insulin release than a comparable glucose load given intravenously (Hansotia & Drucker, 2005)

SAM is regenerated again and again in a permanent cycle: it releases its methyl group in various reactions, and then goes through a series of reaction steps, through which it receives a new methyl group and is thus available again as a methyl donor

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