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Glucagon-like peptide 1 receptor agonists have the potential to revolutionize the attainment of target alC levels in type 2 diabetes-so why is their uptake so low

Oral route data in rodents shows genuine GI-local effects, but systemic bioavailability from capsules is unquantified in humans, meaning dose-response claims for joints and tendons rely on injection-route animal studies

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doi: 10.1016/j.molmet.2022.101638 87 GasbjergLSHelstedMMHartmannBSparre-UlrichAHVeedfaldSStensenSet al

Appropriate supplementation, when indicated based on individual assessment rather than routine use, can help address nutritional gaps during tirzepatide therapy