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The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death (Huang et al., 2025)

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Researchers exploring peptides for menopause weight loss or peptides for fat loss should be aware that rapid weight loss increases gallstone risk regardless of the method used