Evidence Strength Rating Moderate plausibility via reduced intake Limited direct clinical outcome data 4.2 Vitamin B12 Physiological Role Vitamin B12 supports: Neurological function Red blood cell production DNA synthesis It is primarily obtained from: Meat Dairy Fish Why GLP-1 Therapy May Influence B12 Possible mechanisms: Reduced intake of animal products Chronic low-calorie intake Gastric acid modulation secondary to delayed gastric emptying (theoretical) Unlike metformin, GLP-1 drugs are not known to directly impair B12 absorption
Below is a summary (definitely not exhaustive) for the landscape of weight loss drugs in development (including company name and formulation, dosing and mechanism), showing my estimation of when these could launch and become available for patients
Women planning pregnancy are advised to stop treatment at least 2 months before trying to conceive, as the drugs may affect fetal development
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Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq