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3.5 Cox analysis of serum GPX-3 concentration for each poor outcome Serum GPX-3 concentration at diagnosis was not significantly associated with all-cause mortality, ESKD, CVA, or ACS during follow-up in patients with AAV (Table 5)
A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation
The effect is sharpest during aerobic exercise, where fat is already the body's primary fuel source
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