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Additionally, case fatality rates specific to MI, unstable angina, stroke, knee replacement and bariatric surgery, as well as HRs representing higher mortality rates post-acute coronary syndrome, stroke, and diabetes, observed in the general population, were applied in the model in the cycle in which each event occurred (Supplementary tables S7, S8, S9)

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Visual inspection of Schoenfeld residuals showed no violation of the proportional hazards assumption, and the P value for interaction with the natural logarithm of time was 0.83

In addition to weight loss, participants who received semaglutide also showed improvements in their blood pressure, cholesterol levels, and blood sugar control