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It is engineered with two structural modifications relative to the 70-residue native protein: a substitution of arginine for glutamic acid at the third position and a 13-amino-acid extension at the N-terminus, giving a total length of 83 amino acids

De Rosa SC, Zaretsky MD, Dubs JG, et al

Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation

Furthermore, there are no standardized clinical tests to establish the long-term safety

A 90% pure peptide behaves differently than a 98% pure peptide, and impurities in injectable-grade products carry safety implications that are not theoretical