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Conversely, adding an SGLT2i to a GLP-1RA did not yield a statistically significant further reduction in HbA1c (SMD 0.11%), suggesting that the glycaemic benefit of combination therapy is predominantly driven by the GLP-1RA component

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In tissues with abundant mitochondria and active oxidative metabolism, PGC-1 is expressed at high levels, and its expression is significantly increased by physiological signals such as exercise and fasting [20]

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