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Position 2 (Alpha-aminoisobutyric acid, Aib) : The substitution of the natural amino acid at position 2 with the non-natural alpha-aminoisobutyric acid (Aib) residue is a well-established strategy for conferring resistance to dipeptidyl peptidase-4 (DPP-4) cleavage

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Patients with a history of pancreatitis should be monitored closely, and urgent medical attention should be sought for severe abdominal pain radiating to the back

Use effective contraception while taking these medications

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