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This compound is supplied exclusively for in vitro research purposes
Most research is preclinical or small
Recent studies using both in vitro and in vivo models indicate that glycyrrhizin directly targets and binds to the RNA-binding protein CUG-binding protein 1(CUGBP1), activating the Interferon (IFN)-/Signal Transducer and Activator of Transcription (STAT)1/Smad7 signaling pathway and thereby inhibiting HSC activation, ultimately exerting anti-fibrotic effects (Guo et al., 2023)
This level of efficacy approaches that of sleeve gastrectomy (25-30% at 1 year) and represents a transformative advance in non-surgical obesity treatment
That finding led Eli Lilly to seek approval to market tirzepatide for weight loss as Zepbound
