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Structural analysis of the wild-type HsaGST A2-2 and HsaGST A3-3 shows that the steroid substrate is not binding to HsaGST A2-2 in an orientation compatible with ketosteroid isomerase activity, apparently explaining the different activities of the two enzymes (Tars et al., 2010)

A stronger skin barrier means better moisture retention, reduced sensitivity, and improved protection against environmental stressors that accelerate the aging process

However, they are also the most expensive and most time-consuming option