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Ghrelin stimulates gastric acid secretion and motility in rats

When you eat, your body releases GLP-1, which signals the brain to reduce hunger, slows the emptying of the stomach (promoting a feeling of fullness), and stimulates the pancreas to release insulin in response to rising blood sugar

Each of these drugs slows the processing of food through the digestive tract, which sends messages to patients brains that theyre hungry, resulting in a diminished appetite