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Melanotan II was originally developed as a tanning agent based on an earlier drug called afamelanotide (previously "Melanotan I") [1] which is now approved by the FDA for the treatment of a particular rare genetic form of sun sensitivity

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However, treatment with APR-246 resulted in a clear decrease in the amount of free thiols in mutant p53-carrying Saos-2-His-273 cells, as the amount of fully reduced thiols was decreased from 76.3% to 17.0%, and as the amount of Trx1 without any free thiols (SH-0) increased with 8%, We obtained similar results for Trx2, where almost 50% of Trx2 in Saos-2 cells was in the fully reduced form and 63% in Saos-2-His-273 cells (Fig

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Last updated 11/22/2024

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