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Key Points : Common symptoms associated with vocal nodules include progressively worsening hoarseness, breathiness, rough or scratchy voice, decreased pitch range, neck tightness or discomfort, diminishing voice quality with use, and vocal exhaustion

These include the deficiencys severity, underlying medical conditions, and how well the patient responds to treatment

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The released ROS activate the ion channel TRPM2 in macrophages, promoting calcium influx, thereby eliciting an immune response