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Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

B12 supports normal energy metabolism and red blood cell production, so correcting a genuine deficiency can help you feel and perform like yourself again, but shots are not a proven performance enhancer for people who are not deficient

Speich, J

They are not FDA-approved drugs