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The study also reported that Setria may help wrinkle reduction in middle-aged women by improving water retention in sun-exposed areas of skin, aiding in hydration and possibly an improved skin barrier. It was previously reported that oral GSH administration at 500 mg/day may help in brightening of skin color, and the main objective of this study was to find out whether Setria Glutathione maintains its skin brightening efficacy when given at a dose of 250mg/day, said Yuki Nakamura, researcher at Kyowas Healthcare Product Development Center