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K.MaxsonR.et al (2008)
Weight loss with resultant loss of truncal adiposity correlated with decreased CSF pressure [3]
3c), compounds 1 - 5 were found to be slow inhibitors as they displayed little to no inhibition after 15 min, but time-dependent inhibition of TGR over 25 h (Fig
108 (52): E1470E1474
And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat
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