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Similar observations on gene expression were made in adipocytes of mice, when mice that had gained weight on a 12 week high-fat diet followed by weight loss on a chow diet were compared to mice of similar body weight that were maintained on the chow diet for the whole period [20]
The SURPASS clinical trial program for type 2 diabetes showed sustained HbA1c reductions for up to 104 weeks, while the SURMOUNT-1 trial demonstrated progressive weight loss over 72 weeks for chronic weight management
doi: 10.1146/annurev.pharmtox.010909.105753 33 MutohTRiveraRChunJ
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