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At 72 weeks, all doses (6 mg, 12 mg, 36 mg) met the primary endpoint of superior body weight reduction versus placebo and achieved key secondary goals including 10%, 15%, and 20% weight loss and reduced waist circumference
To assess differential item functioning (DIF), we used the lordif package in the R platform, which uses an ordinal logistic regression framework and graded response model for IRT trait estimation
Most noticeable symptoms ease within one to three months after stopping, though this varies based on dose, treatment length, and individual health factors
Tirzepatides indirect impact on cardiovascular system Glucose and lipid metabolism The study conducted by Karagiannis et al
Sandoval and DAlessio (2015)
