doi: 10.1016/j.ejphar.2021.173887 165 MaYYuWShrivastavaAAlemiFLankachandraKSrivastavaRKet al
Allergic reactions to tirzepatide are rare but can include rash, hives, difficulty breathing, or swelling of the face or throat
Indeed the GLP-1(7-36) NH2 receptor, a GPCR, is found to be expressed by a wide range of tissues and cells such as: , , and -cells (169), sinoatrial node myocytes, arterial smooth muscle cells of lungs and kidneys, megakaryocytes, macrophages, monocytes, lymphocytes, gastrointestinal tract mucosa [mainly Brunner's gland in the duodenum, but also in the parietal cells of the stomach, jejunum ileum and the nerve plexus around the small and large intestine (170, 171)], central nervous system [neocortex, cerebellum, thalamus, amygdala, area postrema, hypothalamus, hippocampus, nucleus tractus solitarius (158)], peripheral nervous system (myenteric plexus) and in the skin (172176)
It supports the maintenance and repair of nerve cells, promoting overall neurological health
Until the completion of these recent trials, metformin was the only drug with evidence for CV benefit, albeit in very modest numbers of patients with small number of events and relatively low event rates (81)