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Any new or worsening symptoms while on therapy, including severe abdominal pain, persistent nausea or vomiting, or signs of gallbladder disease, require prompt medical evaluation

Newer labels such as Tirzepatide also warn about pulmonary aspiration risk during anesthesia because these drugs can delay stomach emptying [15]

Shefflette A, Patel N, Caruso J

doi: 10.3389/fmolb.2023.1130625 Received 28 December 2022 Accepted 08 May 2023 Published 23 May 2023 Volume 10 - 2023 Edited by Hem Chandra Jha, Indian Institute of Technology Indore, India Reviewed by Finbarr P

Longer treatment durations up to several months have been examined in chronic disease models without apparent tolerance development or diminishing efficacy