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GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1 = Glucagon-like peptide 1

Primary and Secondary Endpoints The primary endpoint was the percentage change in body weight from baseline to 72 weeks

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In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonist, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. How do drugs like Wegovy and Mounjaro work