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Lyophilised Powder: Prior to reconstitution, Retatrutide is typically stored frozen at approximately -20C
The SURMOUNT-4 trial (NEJM, 2023) demonstrated that continued treatment is necessary to maintain weight loss, as participants who discontinued tirzepatide after achieving weight loss regained significant weight during the withdrawal phase
To date, research findings have been mixed on whether GLP-1 receptor agonists can help break this cycle
doi: 10.1038/ki.2014.246 44 Mori ITI
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