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Rather than introducing synthetic growth hormone directly into the body, this peptide combination signals your pituitary gland to produce and release its own growth hormone in natural pulses

Saxenda, the second to be approved, only achieved middling weight-management results for a large share of those who took it, and physicians were reticent to prescribe weight-loss medications after the disastrous effects of drugs such as fen-phen were revealed in the late 90s

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The answer is absorption

This earlier study was uncontrolled, however, but justified the subsequent controlled trial